The Jeff Kimball House is a historic residence in the village of Mechanicsburg, Ohio, United States.

During the late nineteenth century, multiple prosperous farmers owning land near Mechanicsburg constructed or purchased houses along Main Street north of downtown, instead of living on their farms; some of the more prominent ones were Jeff Kimball, Henry Burnham, and Neil Gest, whose homes are today known as the Jeff Kimball, Henry Burnham, and Demand-Gest Houses.

[1] One of Mechanicsburg's better Queen Anne residences,[3] the Jeff Kimball House is a brick building with a stone foundation, a slate roof, and additional elements of brick and stone.

[4] Although its neighborhood includes all of the village's best houses, the two-and-a-half-story Kimball House nevertheless stands out by means of details such as its ornamental front porch, its ironwork, its stained glass windows with bevelling, and the elaborate basketweave-like pattern of its brickwork.

It was one of approximately twenty different Mechanicsburg locations to be listed on the National Register at the same time as part of a multiple property submission.