It is located on Arkansas Highway 365, 4.8 miles (7.7 km) south-southeast of Redfield and is the home of the National Center for Toxicological Research (NCTR).

[3] Jefferson was founded on October 3, 1881,[4] the result of the newly built Chicot to Little Rock railroad.

Jefferson is home to the National Center for Toxicological Research and is co-located with the Office of Regulatory Affairs’ Arkansas Regional Laboratory.

The Jefferson Laboratories campus sits on 496 acres (201 ha) in the midst of a beautiful pine forest.

[5] NCTR is the only Food & Drug Administration (FDA) Center located outside the Washington D.C. metropolitan area.