Jefferson Park is 9.1 miles (14.6 km) away from Ogilvie Transportation Center in downtown Chicago, the inbound terminus of the Union Pacific Northwest Line.

As of 2018[update], Jefferson Park is the 97th busiest of Metra's 236 non-downtown stations, with an average of 510 weekday boardings.

It is also an 'L' station on the Blue Line, which stops at a single island platform in the median of the Kennedy Expressway at 4917 North Milwaukee Avenue.

The middle track is a remnant of a small storage yard that existed from 1970 to 1983 when Jefferson Park was the line's northern terminus.

The $25 million project began at the Jefferson Park Transit Center on October 1, 2018, and was completed on July 23, 2019.