Jefferson sponsors 17 varsity intercollegiate teams: Men's sports include baseball, basketball, cross country, golf, soccer, tennis and track & field; while women's sports include basketball, cross country, golf, lacrosse, rowing, soccer, softball, tennis, track & field and volleyball.

Magee served 54 years as coach at Philadelphia University, highlighted by an NCAA Division II Basketball Championship in 1970.

Magee was awarded the honorary degree of Doctor of Humane Letters by President Stephen Spinelli Jr. at Philadelphia University's 125th Commencement in 2009.

The program has produced multiple professional players, to include Bob File,[2] Curtis King,[3] and Abraham Almonte.

In 2021, Jefferson also earned its fourth NCAA Tournament appearance (2014, 2015, 2019), and the Rams made back-to-back trips for the second time.