Jefferson Van Horne (December 12, 1802 – September 28, 1857) was an American infantry officer.

[1] Van Horne graduated from the United States Military Academy with a rank of thirteen in a class of thirty-eight.

[1] As a second lieutenant he was on frontier duty at Jefferson Barracks Military Post, Missouri from 1827 to 1829; at Fort Leavenworth, Kansas in 1829; Jefferson Barracks Military Post, Missouri from 1829 to 1930; Natchitoches, Louisiana from 1830 to 1831, Fort Towson, Territory from 1831 to 1832 on Commissary duty;[2] and transferring and subsisting Indians from 1832 to 1839.

[1] Van Horne fought in the Seminole Wars from 1840 to 1842, was promoted to captain on December 1, 1840, then stayed in garrison at Fort Stansbury, Florida from 1842 to 1843.

[4] Van Horne married Mary S. Gilbert in Zanesville, Ohio on November 28, 1854.