Jefferson and Powell station is a light rail station in the Fisherman's Wharf district of San Francisco, California, serving the San Francisco Municipal Railway's E Embarcadero and F Market & Wharves heritage railway lines.

The station opened on March 4, 2000, with the streetcar's extension to Fisherman's Wharf.

The stop is also served by the route 39 bus, plus the L Owl bus route, which provides service along the F Market & Wharves and L Taraval lines during the late night hours when trains do not operate.

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