Elizabeth briefly ruled as regent for her eldest son, Stephen II, in 1314.

Elizabeth was a daughter of King Stefan Dragutin of the Nemanjić dynasty.

Elizabeth was the second of four children; her brother was Stephen Vladislav II of Syrmia.

The marriage was political and arranged by Ban Prijezda II who had attempted to forge an alliance with Stephen Dragutin (Elizabeth's father).

According to a 1601 source whose reliability is unknown, Elizabeth fled to the Republic of Ragusa (Dubrovnik) and died around 1331.