[1] The series features Bill Klein, a businessman, and Dr. Jennifer Arnold, a neonatologist, who both have skeletal dysplasia.

The show begins with the couple having just moved to Houston, Texas, where the series has documented the customized building of their home and attempts to have a child.

Arnold is a neonatologist[2] who works at the Texas Children's Hospital, and Klein is a medical supplies and telemarketing businessman.

[11] Season 5 began on March 20, 2012, and follows Klein and Arnold as they move into their custom-built dream home and launch a brand-new business.

[16] In December 2013, Arnold revealed that she was diagnosed with a rare form of cancer, stage 4 choriocarcinoma, due to a non-viable pregnancy she had suffered in September 2013.