[2] She is best known for her work in video game franchises such as Baldur's Gate, Mass Effect, Metal Gear Solid, BioShock Infinite, Metroid Prime, Halo, Overwatch, and Star Wars: Knights of the Old Republic.

[4] Hale is featured in animation such as The Real Adventures of Jonny Quest, The Powerpuff Girls, Codename: Kids Next Door, The Grim Adventures of Billy & Mandy, Brandy & Mr. Whiskers, Totally Spies!, Avatar: The Last Airbender and its continuation The Legend of Korra, Where on Earth Is Carmen Sandiego?

In 2022, she has been nominated for "Performer in a Leading Role" at the 18th British Academy Games Awards, as well as "Outstanding Achievement in Character" at the 25th Annual D.I.C.E.

She later told Tom Bissell of The New Yorker that her biological father, James Learning, was an outdoorsman[2] who was also a prominent NunatuKavut elder and environmental activist.

[14][15] She would later call for support to free her father, who had advanced cancer, after he was imprisoned for refusing to sign an injunction to stay away from Muskrat Falls in 2017.

She was also selected among a group of about six thousand girls in a nationwide search to be in several episodes of the Santa Barbara soap opera television series.

After doing more regional work, she eventually moved to Los Angeles, where she took on sporadic guest roles typical for young actresses on shows such as Melrose Place, ER, and Charmed.

Hale's next animation project was Skeleton Warriors where "there were ten cast members, [two] of whom were girls, and we blew stuff up and cartoon maimed each other every week.

In 1994, she was cast as Felicia Hardy/Black Cat in Spider-Man, the first in a long line of Marvel Comics characters she has voiced.

In a 2004 interview, she said "I'm so happy that David (Michel, creator and producer), Jamie (Simone, voice director) and everyone gave me the opportunity to be part of the show, it's been one of my absolute favorite experiences."

Hale interpreted the voices of Fall-From-Grace and Deionarra in the role-playing computer game Planescape: Torment.

She is also known as the "voice" of Samus Aran in all three games in the Metroid Prime trilogy, providing grunts and screams as the player moves and takes damage.

[3] Hale was also the voice of Jean Grey in Wolverine and the X-Men and Marvel vs. Capcom 3: Fate of Two Worlds as well as a small role in Swat Kats.

Hale was selected to voice Commander Shepard, the main player character in the Mass Effect series.

[35] In February 2023, Hale guest voiced Riyo Chuchi, a Pantoran member of the Imperial Senate, in Star Wars: The Bad Batch.

[38] In an interview with The Geek Forge regarding her influences, Hale cited voice actors such as Dee Bradley Baker, Grey DeLisle, Phil LaMarr, Tress MacNeille, Kath Soucie, Frank Welker, and April Winchell, with emphasis on LaMarr.

"[39] Hale lived in the Los Angeles area, but since 2020, she has relocated back to Canada and now resides on Vancouver Island where she continues to do voice recordings from her personal home studio.