She was appointed to that position in April 2011 by the President of Uganda, following the creation of the new institution that replaced Kampala City Council.

The following year, she obtained the Diploma in Legal Practice from the Law Development Centre in Kampala, the capital of Uganda.

[6][9] The exhaustive list of qualifications attained and training programs undertaken by Musisi are presented below.

[6] Musisi briefly worked as a State Attorney in the Directorate of Public Prosecutions and moved on to become the Assistant Secretary Legal Affairs for Makerere University.

Together with Allen Kagina, Musisi led the formulation and implementation of the Institutional Reforms and Restructuring Programme at Uganda Revenue Authority.

Her role as Commissioner Legal Services and Board Affairs also involved working closely with the Commissioner General and the Senior Management Team, the Board of Directors and various stakeholders including government ministries, the Tax Appeals Tribunal and the Uganda judicial system.

[6] In 2011, Musisi was appointed by the President of Uganda as the first Executive Director of the Kampala Capital City Authority.

[4] However, on 15 October 2018, she tendered her resignation as KCCA Executive Director, effective 15 December 2018, citing inadequate funding and irreconcilable competing interests between the KCCA Technical Team and politicians, that made it increasingly difficult to achieve the set transformational targets.