The band was founded when Wayne, Caroline Cutbirth, and Tayla Lynn, were recruited for a reality television series titled All in the Genes, which would focus on the ups and downs of the descendants of famous relatives; Wayne is John Wayne's granddaughter, Cutbirth is a descendant of Daniel Boone,[6] and Tayla Lynn is the granddaughter of Loretta Lynn.

Their second single, "Paper Heart", was released in May 2011 and reached a peak of number 59 after two weeks on the chart.

[10] Wayne appeared as a contestant on the twenty-second season of the CBS reality competition series The Amazing Race, which was filmed between November 13, 2012 and December 7, 2012, and was broadcast between February 17, 2013 and May 5, 2013, alongside Cutbirth.

[12] Wayne made her debut as an actress with the role of Amy in the Christian drama film Like a Country Song, starring Billy Ray Cyrus and Jennifer Taylor.

[16][17] The three met in Nashville and wrote their debut single "Lipstick" with assistance from Rebecca Lynn Howard, Caroline Hobby (a former member of Stealing Angels), and Elisha Hoffman.

They released their self-titled debut EP in September 2018, which featured the singles "Wild West" and "But My Own Drinks".

[16][17][10][18][19] The group was a supporting act for Carrie Underwood on her Cry Pretty Tour 360, which ran from May 1, 2019 to October 31, 2019, alongside Maddie & Tae.

"Buy My Own Drinks", which served as the lead-off single, is included on the album alongside three other songs from their previous EP release.

After "Buy My Own Drinks", the band also charted two more singles from the album, "Head over Heels" and "We Were Rich".

[28] In 2023, Runaway June signed with Quartz Hill Records and released "Make Me Wanna Smoke" as their first single under the new label.

[34][35] Wayne and Cutbirth appeared as clue givers during the finale episode in the thirty-fourth season of The Amazing Race.

[36] Wayne appeared on The Design Network's 2023 reality television series Flip U with Brad Rempel.

[37] Wayne met her future husband, Austin Moody, a singer-songwriter, at Ocean Way Studios in Nashville, Tennessee in 2015.