Jequitinhonha (/ʒekitiˈɲoɲɐ/, [ʒekitʃ͡iˈɲoɲɐ]) is a Brazilian municipality located in the northeast of the state of Minas Gerais.

Neighboring municipalities are: Joaíma, Felisburgo, Rubim, Almenara and Pedra Azul.

The municipality contains most of the 50,890 hectares (125,800 acres) Mata Escura Biological Reserve, created in 2003.

[4] The main economic activities are cattle raising and the cultivation of coffee, sugarcane and corn.

[5] This municipality is isolated from major population centers and suffers from drought and poor soils.