He was suspended for non-conformity in 1636 and soon afterward deprived, he went to Rotterdam (1637) and became "teacher" of the English church there.
He was one of the Five Dissenting Brethren who put their names to the Independent manifesto, An Apologeticall Narration in early 1644.
While one of the most distinguished of the English Independents, he was one of the most moderate, acting consistently in accordance with the motto on his study door (in Latin and Greek): "Opinionum varietas et opinantium unitas non sunt ασυστατα" ("Difference of belief and unity of believers are not inconsistent").
In 1646, Burroughs died from complications resulting from a fall from his horse on the way back from the Westminster Assembly.
Burroughs' publications were many, one of the most important being An Exposition with Practical Observations on the Prophecy of Hosea (4 vols., London, 1643–57), which, along with a number of his other works, has been recently reprinted: