To support his 2001 independent debut album, Back Porch Spirituals, Fisher spent six months touring from Seattle, across Canada to Halifax, Nova Scotia by bicycle.

Let It Shine, his first album on a major label (Sony BMG Music Canada), was released on October 12, 2004.

"High School", the second single from the album, won wide airplay on Canadian commercial radio and music television in early 2005.

Fisher dueted with Canadian industrial music supergroup Jakalope on the track "Unsaid" from their Born 4 album, released in 2006.

He also opened for several of Great Big Sea's Ontario shows in September 2009, eventually making a guest appearance on their 2010 album Safe Upon the Shore.

[4] His first children's album, Highway to Spell, was released on March 9, 2018, and credited to "Jeremy Fisher Junior".

[6] In 2022 he created the children's television series Jeremy and Jazzy, costarring animated versions of Fisher and singer-actress Aiza Ntibarikure.