[2] After graduating from college, Garelick began his career working as an assistant in Creative Artists Agency's Motion Picture Literary department.

While working on Veronica Guerin in 2002, Garelick sold The Golden Tux, a spec script he co-wrote with Todd Phillips, to Dimension Films.

Garelick’s early career came full circle in 2013, when he was hired by Screen Gems to direct and produce The Wedding Ringer, a feature film that evolved from The Golden Tux.

In 2023, Garelick directed Murder Mystery 2, a Netflix movie starring Adam Sandler and Jennifer Aniston.

[5] Under the banner of "American High," Garelick produced two movies: Banana Split for $1.2 million and Holly Slept Over for $500,000.

[4] Garelick subsequently produced the American High films Looks That Kill, The Ultimate Playlist of Noise, and Plan B.

In August 2020, Garelick made his American High directorial debut with The Binge, a spoof of The Purge set in a world in which drugs and alcohol are illegal, except for one day.