Pikser got his start working as a "special consultant" and uncredited writer on the film Reds (a screenplay also co-written by Beatty nominated for an Academy Award).
He wrote The Lemon Sisters and War, Inc. (co-written with Mark Leyner and John Cusack), which premiered at the 2008 Tribeca Film Festival in New York City.
Pikser teaches screenwriting at New York University in the Rita and Burton Goldberg department of dramatic writing at the Tisch School of the Arts and at Johns Hopkins University in the Film and Media program at the Krieger School of Arts and Sciences.
[3] At Oberlin College, he was a leading opponent of the Vietnam War, and he was one of the authors and organizers of the Not in Our Name Statement of Conscience, opposing the U.S. invasions of Afghanistan and Iraq.
In 2019, as vice president of WGA-E, Pikser oversaw the negotiating committee for the WGA-Agency Agreement, and he joined other WGA members in firing his agents as part of the guild's stand against the Association of Talent Agents after the two sides were unable to come to an agreement on a new Code of Conduct that addressed the practice of packaging.