Jermell Charlo vs. Brian Castaño II was a professional boxing match contested on May 14, 2022 for the undisputed light middleweight championship.

[1] On July 17, 2021, Charlo and Castaño faced each other for the first time, battling to a controversial split draw at the AT&T Center in San Antonio, Texas.

Many believed Castaño did enough to win,[2] and much attention was drawn to judge Nelson Vazquez's 117–111 scorecard in favor of Charlo, which was criticized by many prominent figures in the boxing world, including Andre Ward, Lou DiBella and Eddie Chambers.

[8] A day later, the WBO ordered Castaño to show cause as to why Charlo shouldn't be scheduled to make an overdue mandatory title defense against Tim Tszyu.

[11] Like the first fight, the rematch was competitive, the two men spent the opening rounds trading blows before Charlo began to build a lead.

The second was left to the head and another body shot sent Castano back to the canvas badly hurt, he did not beat the count and Charlo was awarded a KO victory.