Jerome Bunty Chaffee (April 17, 1825 – March 9, 1886) was an American entrepreneur and United States Senator from Colorado.

He moved to Adrian, Michigan in 1844 and worked as a teacher until starting a dry goods business in the late 1840s.

In 1852, he moved to St. Joseph, Missouri, and later to Elmwood, Kansas Territory where he started banking businesses and engaged in land speculation.

Chaffee entered politics and helped organize the Colorado Territory, serving in its first legislature as speaker.

In 1876, after Colorado was admitted to the Union, Chaffee was elected to the United States Senate.