Jerome Van Crowninsfield Smith (July 20, 1800 – August 21, 1879) was an American physician, author and politician, serving as the fourteenth mayor of Boston, Massachusetts from 1854 to 1855.

Although nominated for mayor in 1858 by both the People's Union [15] and National American parties,[16] he declined to run.

He toured Europe and the Near East in 1850-51 and while abroad served as a juror for the American Industrial Exhibition at the London World's Fair.

[20] During the Civil War, he volunteered to serve with the United States Christian Commission and was stationed with Union forces in New Orleans between October 1863 and August 1865.

Colored Infantry (Old Organization)[22] and was appointed by General Nathaniel P. Banks to head a commission overseeing sanitation in the city.