Jerome Weston, 2nd Earl of Portland (16 December 1605 – 17 March 1663) was an English diplomat and landowner who held the presidency of Munster, Kingdom of Ireland.
He was the second, but the eldest surviving son, of the 1st Earl of Portland, by his second wife Frances Walgrave.
Weston was elected to Parliament as member for Gatton on 11 March 1628, but there was a double return.
Weston was instead returned for the vacant seat at Lewes, after the previous holder, Sir George Goring, was elevated to the peerage.
In 1632 and 1633, he undertook a diplomatic mission to the courts of France, Savoy, Florence and Venice.