Weeks after she was born, Cobb's family moved to Washington, D.C., where her grandfather, Ulysses Stevens Stone, was serving in the United States House of Representatives.

After Ulysses Stone lost a re-election bid, the family moved back to Oklahoma, where he and Cobb's father worked as automobile salesmen.

The family later moved again to Denver, Colorado, before finally returning to Oklahoma after World War II, where Cobb spent the majority of her childhood in Ponca City.

[9] Facing sex discrimination and the return of many qualified male pilots after World War II, Cobb took on less-sought-after flying jobs, such as patrolling pipelines and crop dusting.

Cobb played women's softball for money on a semi-professional team, the Oklahoma City Queens, to save up to buy a surplus World War II Fairchild PT-23 so that she could be self-employed.

[2] In November 1960, following a number of crashes of the Lockheed L-188 Electra, American Airlines' marketing department identified that the aircraft's reputation was poor among women, which was adversely affecting passenger bookings.

"[18][2][19] Cobb then began over 30 years of missionary work in South America with MAF, performing humanitarian flying (e.g., transporting supplies to indigenous tribes), as well as surveying new air routes to remote areas.

Cobb "pioneered new air routes across the hazardous Andes Mountains and Amazon rain forests, using self-drawn maps that guided her over uncharted territory larger than the United States".

[6] In 1999, the National Organization for Women conducted an unsuccessful campaign to send Cobb into space to investigate the effects of aging, as John Glenn had done.

Specifically, NASA wanted to see whether the effects of weightlessness had positive consequences on the balance, metabolism, blood flow, and other bodily functions of an elderly person.

[24] Cobb received numerous aviation honors, including the Harmon Trophy and the Fédération Aéronautique Internationale's Gold Wings Award.

When Haverstick suggested that June Cobb had flown a plane waiting at Redbird Airport, Dallas, on November 22, 1963, the day President Kennedy was killed, which had been standing on the runway for an hour with engines running, and was rumored to be the get-away plane for Lee Harvey Oswald, Jerrie Cobb reacted strongly, but gathered herself and said, "I was at the Redbird Airport."

Cobb is the main character in a 2023 book by Mary Haverstick titled "A Woman I Know: Female Spies, Double Identities, and a New Story of the Kennedy Assassination" This article incorporates public domain material from websites or documents of the National Aeronautics and Space Administration.