Cruz began his professional career by signing with the Sultanes de Monterrey of the Mexican League on March 30, 2017.

In 2018, Cruz split the season between the Single-A Peoria Chiefs and the High-A Palm Beach Cardinals, pitching to a 7–1 record and 3.27 ERA with 104 strikeouts in 30 total games.

He spent the 2019 season split between the Double-A Springfield Cardinals and the Triple-A Memphis Redbirds, but struggled overall to the tune of a 6.02 ERA with 89 strikeouts, a 13.1 K/9 and 6.8 BB/9 in 52 contests between the two affiliates.

[4] Cruz was selected to the 40-man roster and promoted to the major leagues for the first time on August 18, 2020,[5] and same day he made his MLB debut.

[6] He made his major league debut that day against the Chicago Cubs, allowing two earned runs in an inning of relief.

Cruz was part of the Mexican squad that won the bronze medal at the 2023 Pan American Games contested in Santiago, Chile in October 2023.