Its humble beginnings started as it was home of Jesse Andrew, a vibrant member of the early West Lafayette community.

Four of the most recent residents (2016-2018) were students at Purdue named Matthew Mills, Gregg Ray, Ben Claywell, and the one and only Daniel Grimm III.

"The Jesse Andrew House is significant as the oldest home extant in West Lafayette, and as the residence of one of the town's founders.

Subsequent owners of the home included Jesse Charles Andrew's brother, Thomas, and his son, Joseph, both of whom achieved local prominence.

His son, Joseph H. Andrew, who later owned and occupied this structure, was active in the American Red Cross, and served on that organization's National Board of Governors.

"[2] "The Jesse Andrew Home is a two-story Greek Revival structure located on the south side of West Lafayette, near the Purdue University campus.

The home is basically an ell-shaped structure with a gable roof; a small, hip-roofed wing, possibly a later addition, projects from the rear facade.

The middle bay, located slightly south of center, originally contained a window, but was converted into a doorway in the 1880s to provide access to the porch roof deck.