Sometime in the early 1880s, Dr Frankenstein's evil granddaughter Maria has moved to the American West with her brother Rudolph, in order to use the prairie lightning storms in her experiments on immigrant children snatched from a dying town.

After a number of failures (owing to Rudolph secretly poisoning the victims as soon as his sister revives them), they are finding it increasingly difficult to hide the trail of bodies.

Down the road, Mañuel Lopez and his wife Nina decide to leave town with their daughter Juanita because of the frequent disappearances, the latest of which is that of their son.

Meeting up with Butch Curry, the head of a local gang called The Wild Bunch, they join up with the intention of stealing $100,000 from the next stagecoach.

However, a member of the gang, Butch's own brother Lonny, decides to go to the sheriff and let him know about the plot in exchange for becoming his deputy and claiming the reward for James' capture.

After a failed attempt to seduce Jesse, Maria sends him to the town pharmacist with a note, then begins operating on Hank, giving him an artificial new brain and bringing him back to life.