[4] Rodríguez made his professional debut against Mauricio Cruz on March 10, 2017, after being discovered by Danny Rangel, winning by unanimous decision.

[5] Rodríguez was scheduled to face Marco Sustaita on February 29, 2020, on the undercard of the Mikey Garcia versus Jessie Vargas bout.

[6] Rodríguez was next scheduled to face the one-time WBC light flyweight title challenger Janiel Rivera on September 5, 2020.

[7][8] Rodríguez was scheduled to fight Saul Juarez on December 12, 2020, on the undercard of the Shakur Stevenson and Toka Kahn Clary junior lightweight bout.

[18] Rodriguez was scheduled to make his first title defense against 35 year old veteran, former super flyweight titlist Srisaket Sor Rungvisai on June 25, 2022.

The title bout was booked as the main event of a DAZN broadcast card, which took place at the Tech Port Arena in San Antonio, Texas.

[19] Rodriguez won the fight by an eight-round technical knockout, stopping Sor Rungvisai with a flurry of punches at the 1:50 minute mark.

The fight was scheduled as the co-headliner of the Canelo Álvarez vs. Gennady Golovkin III DAZN pay per view, which took place at the T-Mobile Arena in Paradise, Nevada on September 17, 2022.

[25] On October 28, 2022, the WBO ratings committee approved a request for Rodriguez to be ranked as the top contender at flyweight and immediately challenge for the title.

[30] Rodriguez faced the four-time defending IBF flyweight champion Sunny Edwards in the main event of a DAZN broadcast show on December 16, 2023, at the Desert Diamond Arena in Glendale, Arizona.

[34] It was reported on March 19, 2024, that Rodriguez was in negotiations with 34 year old veteran and WBC super flyweight champion Juan Francisco Estrada.