Jesse Sene-Lefao (born 8 December 1989) is a Samoa international rugby league footballer who plays as a prop or second-row forward for the Sheffield Eagles in the RFL Championship.

Sene-Lefao has previously played for the Manly-Warringah Sea Eagles and the Cronulla-Sutherland Sharks in the NRL, plus Castleford Tigers in the Super League.

He made his NRL debut in the opening round of the season against the Brisbane Broncos at Suncorp Stadium, playing off the interchange bench in Manly-Warringah's 22–14 win.

[9][10] In round 13 against the Canterbury-Bankstown Bulldogs at Brookvale Oval, Sene-Lefao scored his first NRL career try in Manly's 32–10 win.

He was a vital squad member for Cronulla-Sutherland in 2016, filling in for captain Paul Gallen during the semis, and the injured Sam Tagataese towards the end of the season.

[16][17][18] In the 2018 Super League season, he made 17 appearances for Castleford as the club finished third on the table but failed to reach the grand final.

[24] On 31 October, he signed a two-year deal to join fellow RFL Championship side Sheffield ahead of the 2023 season.