Alupo trained as a high school canteen attendant before she underwent the officer cadet course at the Uganda Junior Staff College in Jinja.

She holds a Bachelor of Arts in political science and linguistics, obtained in 1997 from Makerere University.

[3] Over the years, she has been employed in various capacities including: In 2001, she entered politics as a candidate for the Katakwi District women's representative.

She ran on the ticket of the National Resistance Movement (NRM) political party.

In the cabinet reshuffle of 27 May 2011, she was promoted to the post of minister of education and sports.