[1] In 2014, while a student at the University of Texas, she worked as an intern in the Washington, D.C. office of Congressman Henry Cuellar, after developing an interest in immigration law reform.

[13] In 2020, Cisneros was a Democratic candidate for the U.S. House of Representatives in Texas's 28th congressional district against Henry Cuellar, the incumbent since 2005.

[15] She also criticized Cuellar's voting record as too conservative, noting in particular his views on abortion rights and his campaign donations from the private prison industry, especially in light of the controversial migrant detention facilities operated at the border by the Trump administration.

Senators Bernie Sanders and Elizabeth Warren, and the abortion rights advocacy groups NARAL Pro-Choice America and EMILY's List.

[25][1][29] On May 2, Politico published a leaked draft majority opinion written by U.S. Supreme Court justice Samuel Alito to overturn Roe v. Wade and Planned Parenthood v.

[30] Before the draft opinion was leaked, NARAL Pro-Choice America announced further support for her campaign, including advertising and organizing efforts.

[39] On June 7, the race remained uncalled by the Associated Press and CBS News, and Cisneros filed a recount petition.