[2] Before her family moved from Europe to the States, their last name was Kirschenbaum which means “cherry tree.”[3] Her mother is a therapist who treated clients in Kirson's childhood home, which she has said has had a profound impact on her and her comedy.

[10] In 2016, Kirson acted in and served as a consultant, producer, and writer on the Robert De Niro film The Comedian.

[11] Kirson was an executive producer and appeared in the documentary Hysterical which follows a group of female comedians, on and off stage.

[13] Kirson is also a contributor on The Howard Stern Show, where she produces and stars in prank calls for the program.

In her comedy, Kirson often narrates personal experiences of sobriety,[14] her Jewish upbringing, and her identity as a lesbian, utilizing "gallows humor" and "biting, often crass asides.