After an introduction, Mayfield and Auerbach hit the studio, laying the foundation of her debut album With Blasphemy So Heartfelt.

Dr. Dog’s Scott McMicken and Frank McElroy provide vocal harmonies on the track “I’m Not Lonely Anymore.” Says Auerbach of the recording experience, “I think she’s dark and moody in a mysterious way, not unlike Nick Cave and the Bad Seeds.” He adds, “I’m just always really excited to make music with her.” With Blasphemy So Heartfelt debuted with quite a buzz around it.

Mayfield released her second LP Tell Me on February 8, 2011; with her song “Our Hearts Are Wrong” being featured on the hit TV show, Pretty Little Liars.

Pitchfork said, "Jessica Lea Mayfield’s third album opens with the loud, percussive crunch and grind of an electric guitar, thudding loudly and precipitously— Co-producing with her bass player and husband Jesse Newport, Mayfield keeps the sound loose and roomy, preserving the effect of three musicians huddled in a cramped practice space.

On September 29, 2017, Mayfield's fourth studio LP Sorry Is Gone was released by ATO Records: with the exception of the song "Offa My Hands", which was written and produced by Patrick Damphier, who has worked with The Mynabirds and The Arcs, the album was produced by John Agnello, who has worked with Dinosaur Jr and Sonic Youth, and includes appearances by Seth Avett and Steve Shelley of Sonic Youth.

"[5] In addition to opening for many artists, including The Black Keys, The Avett Brothers, Cake, Band of Horses, Ryan Adams, Ray LaMontagne, and Jay Farrar (Son Volt, Uncle Tupelo), Mayfield has frequently toured as a headliner, and performed at the Blossom Music Center in Cuyahoga Falls, Ohio as part of A Prairie Home Companion in July 2010.