It provides private health care to people in Melbourne, regional Victoria, interstate and overseas.

Jessie McPherson Private Hospital was first established in December 1930 in a central Melbourne church hall when a group of female doctors recognised the need for a new hospital to treat the city's ailing female population.

The hospital became a reality when the then Premier of Victoria, Sir William McPherson donated £25,000 to build a hospital in memory of his mother, Mrs Jessie McPherson.

Subsequently, the Queen Victoria Hospital management was ordered by the then government to transfer its control over Jessie McPherson Community Hospital, so that the Cancer Institute could set up a new treatment centre in that location.

The Queen Victoria Hospital moved at the same time, becoming part of the Monash Medical Centre.