Reyez has written songs for Calvin Harris, Kehlani, Dua Lipa, and Normani, most notably penning the hit "One Kiss", and has collaborated with Eminem on multiple occasions.

[5] Her debut album, Before Love Came to Kill Us, was released on March 27, 2020, to widespread critical acclaim, and saw commercial success, entering at number thirteen on the US Billboard 200.

[8] After graduating, she opted out of post secondary education and instead chose to pursue her music while doing odd jobs on the side.

In 2012, Reyez and her family moved to Florida, where she was primarily bartending and busking on the beach,[7] but she returned to Toronto in 2014 after being accepted to The Remix Project's Academy of Recording Arts.

[9] At the Remix Project, Reyez was mentored by Daniel Daley from Dvsn, and her music was heard by King Louie.

In April 2017, Reyez released her debut EP, Kiddo[11] as well as her short film Gatekeeper, which addressed sexism and exploitation in the music industry.

It specifically was based on her experience with music producer Noel "Detail" Fisher, who was accused of sexual misconduct by multiple women, including artist Bebe Rexha.

Reyez performed "Figures" at the 2017 BET Awards on June 25, 2017[16] and on The Tonight Show Starring Jimmy Fallon on August 8, 2017.

She also had a cameo in the Netflix film, Someone Great and appeared on The Lion King: The Gift, performing (with 070 Shake) and co-writing the song "Scar".

[29] The music video for Reyez's song "Far Away" won the 2020 Prism Prize, with director Peter Huang winning the $20,000 award.