A native of Sheffield in western Massachusetts, Greene started playing the violin at the age of four.

[1] Later, she got a degree from UCLA in ethnomusicology, and joined the Peter Himmelman "Skin" tour, playing violin and singing backup.

Upon returning to Los Angeles, Greene joined the Geraldine Fibbers, with whom she recorded two albums.

[3] Greene has played with a number of artists including Golden Smog, Wilco, RZA, Post Malone, JoAnna James, Atmosphere, Joseph Arthur, Soul Asylum and Dessa.

[citation needed] Her song "Time Bomb" was featured at the end of the Burn Notice season 2 finale called "Lesser Evil".