The interior includes marble pilasters, a dome decorated with scenes from the life of the order's founder, and several organs.
It was completed in 1760 and consecrated to St. Ignatius of Loyola and St. Francis Xavier by the Prince Bishop of Augsburg, Joseph of Hesse-Darmstadt.
Features of the exterior are the twin towered facade of red sandstone, the statues of the four cardinal virtues, the Pheme, by Baroque sculptor Paul Egell, which adorns the 75 m-high dome.
He decorated the dome with scenes from the life of the order's founder, St. Ignatius of Loyola, while the nave had an over 400 square metre fresco whose content referred to the subject of the high altar, namely the Mission of St. Francis Xavier to India.
During the Second World War, the church suffered severe damage from British and American air attacks, especially the choir and the dome.
After the war it was decided to rebuild the church in its historical style with the use of original parts in the reconstruction of the approximately 20 metres high marble altar of Peter Anton von Verschaffelt, and the electoral pews.
In the crossing beneath the dome there are four frescoes representing the continents by the Mannheim Baroque painter Philip Jerome Brinckmann.
In the lobby there are very richly ornamented wrought iron gates made by the Mannheim master locksmith Philip Reinhard Sieber in 1755 and two monuments of the church from 1906.
The main organ case in the west gallery is built according to a design of the elector’s court sculptor Paul Egell.