Bishop Joseph Thomas McGucken invited the Jesuits to develop the high school, and in January 1961 they purchased 21 acres, then part of the Horst Ranch, for the new campus.

[7] The school opened in the fall of 1963, and over the next several years acquired additional land for athletic facilities, faculty residences, and a gymnasium-theater complex.

In June 2011 the team won the Marine Advanced Technology Education Center (MATE) ROV competition which was held at the Neutral Buoyancy Lab in Houston, Texas.

The team of about 20 students from all four years in the school is structured as a company with subgroups working together to design, build, test, and deliver one successful product.

In addition to being the overall champions, the team won awards in Design Excellence, Best Technical Documentation, Best Sales Presentation, and Best Product Demonstration.

[8] Jesuit High School has also produced many rugby players who have gone on to represent the United States National Team at the U-16, U-17, U-19, Collegiate, and Men's levels, detailed below in notable alumni.

This rivalry culminates in the Holy Bowl - an annual, Jesuit-Christian Brothers American football game generally held in Charles C. Hughes Stadium.