Jesus and Mo share a flat[2] (and a bed), and occasionally venture outside, principally to a public house, The Cock and Bull, where they drink Guinness and engage in conversation and debate with an atheist female bartender known simply as Barmaid, who is never drawn[3] but is characterised only as an out-of-frame speech bubble.

The Hindu deity Ganesha made a one-time appearance; both Jesus and Mo mocked his depicted weight and four arms.

[10] As the comic centres on Christian and Muslim figures, the satire is generally directed at the two religions, though some critiques apply to many forms of theism.

[12][13] Members of the London School of Economics Atheist, Secularist and Humanist Society were ordered to cover-up their Jesus and Mo T-shirts at the LSE Students' Union Freshers' Fair in October 2013.

[18] Muslim Liberal Democrat politician Maajid Nawaz tweeted a picture of one of the Jesus and Mo T-shirts, after the cartoon came up in a discussion on a BBC programme The Big Questions.

On the programme, the production team stopped participants from being shown wearing T-shirts with the cartoon, which depicted Jesus saying "Hey" and "Mo" saying "How ya doing?