It has over 3,300 employees and 2,200 volunteers serving over 43,000 New Yorkers annually at its community-based programs, residential facilities, and day-treatment centers in each of the five boroughs of New York City as well as in Westchester County and Long Island.

[22] Lawyer, artist, humanitarian, and writer James N. Rosenberg served on the board of the United Hebrew Charities for a decade, beginning in 1909, and in 1924 was elected vice president of the Hebrew Charities' Desertion Bureau, an organization founded in 1905 that helped Jewish immigrant women whose husbands had deserted them.

[24][25][26][27] After moving to New York City in 1922, civic leader and philanthropist Barbara Ochs Adler was a member of the executive committee of the Jewish Board of Guardians.

From 1934 to 1936, teacher Samuel Slavson, one of the pioneers of group psychotherapy, worked at the Jewish Board of Guardians in New York, a care center for girls and boys with developmental disabilities.

[40][21] It has over 3,300 employees, including over 350 social workers, psychologists, doctors, and nurses, and 2,200 volunteers, serving over 43,000 New Yorkers annually at its community-based programs, residential facilities, and day-treatment centers in each of the five boroughs of New York City as well as in Westchester County and Long Island.

[51] In 2018, the Jewish Board acquired the Alpha Workshops,[52] which provides training in the decorative arts as a licensed school of design for LGBTQ+ adults and/or those living with HIV/AIDS and other disabilities.

In the late 1950s, psychiatrist Dr. Viola Bernard of Louise Wise Services, a prominent New York City Jewish adoption agency in the 1960s, created a policy to separate identical twins for adoption, with the intent that "early mothering would be less burdened and divided, and the child’s developing individuality would be facilitated.

"[53] In 1961, psychiatrist Dr. Peter B. Neubauer, then director of New York's Child Development Center of the Jewish Board of Guardians, began a multi-year "nature versus nurture" twin study to observe how the separated siblings would fare in different environments, from birth to age 12, throughout the 1960s and 1970s.

[57] The parents of the adopted children were also not informed by Louise Wise Services that they were part of a twin or triplet set, and one biological mother to a set of twins separated by Bernard and studied by Neubauer reported that Louise Wise Services did not inform her that her children would be separated.

[61] In 1990, a decade after suddenly ending the study, Neubauer and the Child Development Center of the Jewish Board of Family and Children’s Services arranged to have the locked records kept at Yale University.

[54] The Jewish Board established terms that gave it the power to approve or deny any requests to access the records for the next 75 years.

[54] The study records are currently in the custody of Yale University, under seal until October 25, 2065, and cannot be released to the public without authorization from the Jewish Board.

[54] In 2011, two identical twins who reunited as adults, Doug Rausch and Howard Burack, sent a letter to the Jewish Board requesting to see their records.

To this date, all study subjects who have requested their personal records have received them, albeit heavily redacted and inconclusive.