Pryor was a law clerk for Judge James Larry Edmondson of the United States Court of Appeals for the Eleventh Circuit from 1988 to 1989.

[2] Pryor joined the white shoe law firm of Bondurant, Mixson & Elmore LLP in Atlanta as an associate in 1989, becoming a partner in 1997, a position she held before going on the bench in 2014.

In private practice, she represented both plaintiffs and defendants in civil litigation in state and federal courts at both the trial and appellate level, including in tort law, intellectual property, shareholder resolution, and corporate governance cases.

[2] On February 16, 2012, President Barack Obama nominated Pryor to be a United States Circuit Judge of the United States Court of Appeals for the Eleventh Circuit to replace Judge Stanley F. Birch Jr., who retired in 2010.

[6] On July 30, 2014, Senate Majority Leader Harry Reid motioned to invoke cloture on Pryor's nomination.