[4] While Twiss was studying public policy and music in the College of William & Mary, her parents moved to Custer, South Dakota, and there she got interested in theater.
In March 2018, as a writer on Last Week Tonight, Twiss authored a children's book called A Day in the Life of Marlon Bundo about a fictional day in the life of Marlon Bundo, the real-life pet rabbit of the Vice President of the United States, Mike Pence.
It was written in response to Pence's staunch opposition to same-sex marriage and support of conversion therapy advocate James Dobson.
[10] Rather than a straight-up parody of the Pences' book, A Day in the Life of Marlon Bundo is an actual children's story about marriage equality and democracy.
[10][14] On the day of release, John Oliver promoted the book on Last Week Tonight at the conclusion of an episode mainly dedicated to Pence and his positions on LGBT issues; it became a bestseller and the #1 book and e-book on Amazon the following day, receiving notable praise and selling much better than the crew of Last Week Tonight had expected.