James Michael Eisenreich (/ˈaɪzɪnraɪk/ EYE-zin-ryke; born April 18, 1959) is an American former Major League Baseball player with a 15-year career from 1982 to 1984 and 1987 to 1998.

Eisenreich was the runner on second base when Edgar Renteria hit his walk-off single in the bottom of the 11th inning of Game 7.

He was traded from the Marlins, with Bobby Bonilla, Gary Sheffield, Charles Johnson, and Manuel Barrios, to the Los Angeles Dodgers for Todd Zeile and Mike Piazza.

His .405 batting average and .620 slugging percentage greatly exceed his other career numbers and rank among the most successful of any one player against any team.

In 1990, he was the first recipient of the Tony Conigliaro Award, which is given annually to a Major League Baseball player who has overcome a significant obstacle.