Lefebvre was the 1965 National League Rookie of the Year; he hit .250 with 12 home runs and 69 RBI in 157 games, helping the Dodgers win the World Series.

Lefebvre was first hired as a major league manager by the Seattle Mariners in November 1988, with a two-year contract at $150,000 annually, with incentives and a team option for a third year.

[5] In his second season in 1990, Seattle won 77 games and drew over 1.5 million in home attendance at the Kingdome.

In 1991, the Mariners posted their first-ever winning record at 83–79 (.512) and drew over 2.1 million, but Lefebvre's contract was not extended;[6] he was succeeded by assistant coach Bill Plummer.

His son, Ryan, is the lead play-by-play announcer for the Royals on Bally Sports Kansas City.