[2][3][4] After graduation from Drake University law school, Nussle was elected as the Delaware County, Iowa attorney in Manchester.

[5] Nussle ran as the Republican candidate for Tauke's House seat against Eric Tabor and won.

His position brought national and international interest to his district, including the ONE Campaign, the lobbying group formed by Bono of the rock band U2.

The statement was quickly removed by editors as it violated English Wikipedia policies on maintaining a neutral point of view.

When Iowa Governor Tom Vilsack announced that he would not seek a third term in 2006, a number of people from both parties began exploring running for the governorship.

His only serious primary challenger, Bob Vander Plaats, withdrew from the race to endorse Nussle and become his running mate.

On June 6, 2006, Nussle won the Republican primary, but lost the general election to Iowa Secretary of State Chet Culver on November 7 by a wide margin.

[10] Three Republicans and four Democrats announced their intentions to seek the House seat Nussle was vacating in January, 2007.

[3][12] In 2021, Nussle said that he would no longer affiliate with the Republican Party, following the January 6 United States Capitol attack.