He is known for his soulful vocals and powerful blues rock guitar work.

A founding member of the blues rock trio Mother Superior who as a band have worked with Lemmy, Queens of the Stone Age, Alice Cooper, Meat Loaf, Emmylou Harris, Anthrax, Wayne Kramer, George Clinton, and Iggy Pop.

Mother Superior released their eighth studio album Three Headed Dog in 2007.

Along with the other members of Mother Superior, Wilson has recorded and appeared with Daniel Lanois in 2006, 2007, 2011 and 2014.

He toured with Daniel Lanois and has taken back the mantle of lead singer for Motor Sister, a project of his with Scott Ian (guitar), Joey Vera (bass), John Tempesta (drums), and Pearl Aday (vocals).