[7] In the 100 metre backstroke at the 2022 World Aquatics Championships, with pool swimming competition held at Danube Arena in Budapest, Hungary in June, Leguizamón placed 26th with a time of 1:03.16.

[16][21][22][23][24] On 6 July, the day after the completion of the Games, Colombian newspaper El Tiempo dubbed Leguizamón as an emerging talent, specifically in regards to her potential to compete at the 2024 Summer Olympics.

[25] Leguizamón was one of six Colombian swimmers who entered to compete at the 2022 FINA World Junior Swimming Championships, held in August and September in Lima, Peru.

[27] On day two, she split a 1:04.47 for the butterfly leg of the 4×100 metre mixed medley relay, helping achieve an eleventh-place finish in 4:08.10.

[29] Day four of competition, she qualified for her first final of the Championships in the preliminaries of the 200 metre individual medley, where she ranked eighth with a time of 2:23.74, which was less than 10 seconds behind first-ranked Mio Narita of Japan.

[32] In August, Leguizamón was named to the Colombia roster in swimming for the senior 2022 South American Games, to be held in October in Asunción, Paraguay.

[34] In the 200 metre individual medley on 2 October, she was the highest-placing female swimmer from Colombia in the final, finishing sixth with a time of 2:25.59.