With his second novel, Au-delà de l'Infini [Beyond Infinity] (1952), Guieu introduced the character of American biologist Jerry Barclay and reversed the theme.
In the Kariven series, Guieu began to explore his favorite themes such as UFOs, close encounters, Erich Von Däniken-like theories of ancient astronauts, secret societies, lost civilizations and occult conspiracies.
During 1967, with Le Retour des Dieux [The Return of the Gods], Guieu revamped the Kariven character into that of journalist Gilles Novak who, with the help of his girl-friend Régine Véran, and various friends and allies, often real-life friends of Guieu or thinly-disguised real-life figures, fought against would-be tyrants, communists, terrorists, drug cartels and various alien menaces.
Novak was helped in his struggles by Michael Merkavim, the commander of a new, powerful Order of Knights Templar, equipped with futuristic weapons and based in a parallel universe.
During the early 1990s, Jimmy Guieu wrote two docu-dramas, using as plot the Grey aliens / Majestic-12 conspiracy as described by John Lear and Milton William Cooper : the series "E.B.E."