[9][10][11] Another consolation draw win in Italy and another final defeat to Walraven in Prague followed to close the season.

[14] In 2004, Griffioen lost in the quarterfinals of the Australian Open super series event to Esther Vergeer.

[22] Griffioen also took titles with Maaike Smit in San Diego and alongside Vergeer in Japan Open and Kobe.

As a late replacement in the Paralympic Games, Griffioen exited in the first round of the singles and the quarterfinals of the doubles with Peters.

She was the runner up in Sydney, Miami, Brasilia, Paris, Dutch Open, Hilton Head, Atlanta and San Diego.

[25][26] In doubles competitions with Vergeer, Griffioen won in Sydney, Melbourne, Boca Raton,[27] Paris, Nottingham,[28] Utrecht,[29] Atlanta,[30] San Diego and the Masters.

[33] Playing alongside Maaike Smit Griffioen was the champion in Fukuoka and with Sharon Walraven she took the title in Prostejov.

[35] Griffioen was part of the Netherlands' World Team Cup squad who won the competition for a nineteenth time.

[40][41] With Vergeer in doubles, Griffioen won titles in Sydney,[42] Boca Raton,[39] Japan, Nottingham and San Diego.

[43][44][45] They also won Slam titles in Melbourne and New York;[46][47] before the pair finished the year by winning their third masters doubles.

[49] Griffioen also won in Pensacola and St Louis with Walraven and finished runner up in Nottingham with van Koot.

[69] Notably Griffioen's semifinal defeat to Vergeer in Utrecht marked the first time that she had taken a set off her compatriot.

[75][76] In the doubles events, Griffioen lost in the semifinals of all four Grand Slam tournaments with Florence Gravellier.

[94][95][96] In doubles competitions Griffioen did not partake in the Australian Open due to Homan pulling out through injury.

[95][97][98] Griffioen also reached four doubles finals losing in Florida and Paris;[99][100] but winning in Sardinia and St Louis.

[113] Partnering van Koot in the doubles events the pair won titles in Sydney,[114] Pensacola,[115] Boca Raton,[116] Paris,[117] Nottingham and St.

[125] At the end of season Masters in the absence of Vergeer, Griffioen reached her second final and defeated van Koot for her first title.

[130] In doubles play Griffioen teamed up with van Koot, the pair won six titles including in Cajan,[128] Pensacola,[131] Paris and Nottingham.

[144] During the Grand Slam events, Griffioen lost a tight match to Marjolein Buis in the first round of the Australian Open; with both players having won the same number of points.

[147] At the season ending Masters, Griffioen made it into the final, and let slip a 4–1 lead in the deciding set, to Yui Kamiji, losing the last five games of the match.

[149][150] The pair won their first Australian,[151] French and US Open titles and retained the Wimbledon crown to complete the Grand Slam.

[159] Griffioen won singles titles in Sydney,[160] Baton Rouge,[161] St. Louis,[162] Sardina,[163] Rue and Nottingham during the 2014 season.

[168][169] At the season ending Masters, Griffioen reached the final undefeated, including a win over van Koot,[170] who she lost to in three sets in the championship match.

[171] At the 2015 Australian Open, Griffioen won her maiden Grand Slam singles title; defeating Buis, van Koot and Yui Kamiji in straight sets to win the championship.

[175] Partnering Diede de Groot, she won the women's doubles wheelchair tennis title at the 2024 Australian Open, defeating Yui Kamiji and Kgothatso Montjane in the final.