[6] He made his Bundesliga debut for Schalke on 7 November 2009 against Bayern Munich, in which he scored the game-tying goal and was subsequently named man of the match.

[7][8] After his successful introduction to the first team, Matip remained a regular starter for Schalke in defensive midfield for the remainder of the 2009–10 season,[9] scoring two further goals against 1.

[12] In the 2010–11 season, Matip made his UEFA Champions League debut as Schalke reached the semi-finals of the competition for the first time in the club's history.

On 5 April 2011, he scored his first Champions League goal in Schalke's 5–2 quarter final win against title holders Inter Milan at San Siro.

[14] On 23 February 2013, Matip scored both goals as Schalke recorded an important 2–1 victory over Fortuna Düsseldorf, securing the club's second win in 12 games.

[15] On 15 February 2016, Matip announced signing a four-year pre-contract agreement to join Liverpool on a free transfer, following the expiration of his contract with Schalke.

[28] Matip suffered another muscle injury in July 2018 during a tour of the United States,[29][30] but recovered to be named an unused substitute in a 2–0 away win over Crystal Palace on 20 August.

[citation needed] Despite the showing of interest by new Fulham manager Claudio Ranieri,[33] Matip remained at Liverpool for the rest of the season, establishing himself in the starting eleven.

[citation needed] On 1 June 2019, Matip assisted Divock Origi's goal in the 87th minute of the 2019 Champions League final, which saw Liverpool defeat Tottenham Hotspur 2–0 to win the title.

[37] His 2019–20 season was plagued by injuries, and Joe Gomez quickly took his place as Jürgen Klopp's preferred centre-back to partner Virgil van Dijk.

[38] On 28 January 2021, Matip was substituted at half-time against Tottenham Hotspur, and it was revealed that he suffered ankle ligament injury and would miss the remainder of the 2020–21 season.

[44] On 3 December 2023, Matip came off in the 69th minute in Liverpool's 4–3 home win against Fulham after suffering an ACL injury which would make him miss the remainder of the 2023–24 season.

[67] He married long-term partner Larissa Stollenwerk in the aftermath of Liverpool's 2020 Premier League title,[68] and in June 2021 they welcomed their first child, a son.