While his strikeout total fell (27 in 43 innings), he went 3-0 with a 3.53 ERA and posted a WHIP of 0.99, but a torn anterior cruciate ligament (ACL) ended his season prematurely.

He struck out 84 in 75.1 innings, and his performance during the first half of the season earned him a start in the All-Star Game for the Southern Division of the South Atlantic League.

After his 10-1 performance in 2007, Reyes has moved ahead of left-handed Matt Harrison as the Braves' top pitching prospect.

On July 7, 2007 he was promoted to the Major League ball club, starting in place of the disabled John Smoltz against David Wells and the San Diego Padres.

In his first plate appearance the following inning, he laid down a successful sacrifice bunt to move Jarrod Saltalamacchia to third base.

On July 14, 2010, Reyes and Yunel Escobar were traded to the Toronto Blue Jays for Álex González, Tyler Pastornicky, and Tim Collins.

[1] He made his Blue Jays debut on April 5 against the Oakland Athletics, giving up 9 hits and 5 earned runs over just 3.1 innings.

On May 25, 2011, he lost against the New York Yankees for his 28th consecutive start without earning a win, tying the Major League record set by Cliff Curtis (1910–11) and Matt Keough (1978–79).

[4] In his next start on June 5 against the Baltimore Orioles, Reyes won, pitching 6.1 innings with 4 walks and 3 strikeouts.

[11] Reyes signed a two-year contract with the SK Wyverns of the KBO in Korea in 2013, but was released in early 2014.

[12] In 5 starts for the Triple-A Lehigh Valley IronPigs, he struggled to a 1-3 record and 10.45 ERA with 9 strikeouts over 20+2⁄3 innings of work.

On October 3, 2015, Reyes made his first MLB appearance since 2011, recording one out on one pitch in the 8th inning against the Texas Rangers.