Although he was initially only supposed to be featured in the Chuseok special, his appearance brought in the highest ratings yet for Season 2, so he was announced as a permanent couple.

On June 30, 2010, Jo released his first solo digital single titled, 고백하던 날 (The Day I Confessed), a song he partially composed during the We Got Married broadcast for Ga-in.

[18] The same year, he was cast in the sitcom All My Love with co-stars Park Mi-sun, Kim Kap-soo and fellow idol and former 'wife' from We Got Married Ga-in.

[20] In 2013, Jo joined the cast of a Korean Jesus Christ Superstar musical production, where he played the role of King Herod.

[22] On March 17, 2016, it was announced by JYP Entertainment that Jo would be participating in the musical On The Starry Night as the role "Choi Sung-keun.

On November 10, 2016, it was announced that Jo Kwon would be co-starring on Golden Tambourine,[25] a karaoke variety program broadcast by Mnet, which ran from December 15, 2016, until February 23, 2017.

[28] On July 24, 2019, it was confirmed that he would release a special single new theme song for the ROK Army with collaboration of Shinee's Onew and Key, Exo's Xiumin, Infinite's Kim Sung-kyu, BtoB's Lee Chang-sub, 2AM's Jinwoon, Yoon Ji-sung and actors Kim Minseok, and Lee Jae-kyoon in mid-August.

[29] As part of South Korea's effort to combat COVID-19, Jo officially discharged from the military early on March 24, 2020.

[30] He also made his first variety show appearance after being discharged on JTBC's Knowing Bros alongside 2PM's Wooyoung, Block B's P.O & WINNER's Mino on April 4, 2020.

[34] He entered Kyung Hee University without taking the entrance examination, with rumors alleging favouritism, because he was an entertainer.

[36] Jo is the president of the cereal cafe franchise 'Midnight in Seoul', which was founded and owned by actor-singer Yoon Kye-sang and three friends.

In May 2017, it was announced that the venture would become a franchise and that Jo would be named its president, while Yoon and others would remain official owners.