[1] They are most noted for their roles as Dr. Naadiah in Being Erica, Dr. Mia Stone in PSI Factor, Jerri in Love and Human Remains, Sam in Stonewall, Renee in Slasher: Guilty Party, Amber Ciotti in Slasher: Solstice and Slasher: Flesh and Blood, as well as voice roles in Crash Canyon and My Dad the Rock Star.

[5] In 1991, they won an Emmy Award for Outstanding Performance in a Children's Special in Maggie's Secret,[6] and in 1994 they received a Genie Award nomination for Best Supporting Actress for the film Love and Human Remains.

[7] Vannicola has also appeared in films and television series such as Common Ground, Girlfriends' Guide to Divorce, Rookie Blue, Slasher, Degrassi, Stardom,[8] Betrayal of Silence, The Ultimate Betrayal, Relic Hunter, Mutant X, Kung Fu: The Legend Continues, Night Heat and Derby.

[2] Vannicola founded a non-profit organization to raise awareness about child abuse, Youth Out Loud, in 2004.

[11] An out lesbian prior to coming out as non-binary, Vannicola was a prominent campaigner for same-sex marriage in Canada[12] and is the current chair of outACTRAto, ACTRA's advocacy and support committee for LGBTQ performers.